Welcome to BioISO

Biological networks constraint-based In Silico Optimization

BioISO is aimed at evaluating either the biomass or metabolic network formulation of a given constraint-based metabolic model. This computational tool is based on the Constraints-Based Reconstruction and Analysis (COBRA) and Flux Balance Analysis (FBA) frameworks.

BioISO can receive as input a constraint-based metabolic model in the SBML file format and return either potential errors in the biomass formulation or gaps in the metabolic network.

BioISO can evaluate all reactions associated with a metabolite or just 10% (if the metabolite has more than 20 reactions associated) of them in the complete or fast version, respectively.